Chemoenzymatic synthesis of α-dystroglycan core M1 O-mannose glycans.
نویسندگان
چکیده
The diversity-oriented chemoenzymatic synthesis of α-dystroglycan (α-DG) core M1 O-mannose glycans has been achieved via a three-step sequential one-pot multienzyme (OPME) glycosylation of a chemically prepared disaccharyl serine intermediate. The high flexibility and efficiency of this chemoenzymatic strategy was demonstrated for the synthesis of three more complex core M1 O-mannose glycans for the first time along with three previously reported core M1 structures.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 58 شماره
صفحات -
تاریخ انتشار 2015